Changes of serum metabolites levels during neoadjuvant chemoradiation and prediction of the pathological response in locally advanced rectal cancer.
Jiali LvHuixun JiaMiao MoJing YuanZhenyu WuShuai ZhangFan ZheBingbing GuBingbing FanChunxia LiTao ZhangJi ZhuPublished in: Metabolomics : Official journal of the Metabolomic Society (2022)
This study identified eight metabolites as dynamic differential biomarkers to discriminate NCRT-sensitive and resistant patients. The changes of metabolite level during NCRT show better performance in predicting NCRT sensitivity. These findings highlight the clinical significance of metabolites variabilities in metabolomics analysis.