INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants.
Viviane M AndradeAaron Christensen-QuickJoseph AgnesJared TurCharles ReedRicha KaliaIdania MarreroDustin ElwoodKatherine SchultheisMansi PurwarEmma L ReuschelTrevor McMullanPatrick PezzoliKim KraynyakAlbert SylvesterMammen P MammenPablo TebasJ Joseph KimDavid B WeinerTrevor R F SmithStephanie J RamosLaurent M HumeauJean D BoyerKate E BroderickPublished in: NPJ vaccines (2021)
Global surveillance has identified emerging SARS-CoV-2 variants of concern (VOC) associated with broadened host specificity, pathogenicity, and immune evasion to vaccine-induced immunity. Here we compared humoral and cellular responses against SARS-CoV-2 VOC in subjects immunized with the DNA vaccine, INO-4800. INO-4800 vaccination induced neutralizing antibodies against all variants tested, with reduced levels detected against B.1.351. IFNγ T cell responses were fully maintained against all variants tested.