Transcription factor EB (TFEB)-mediated autophagy protects bovine mammary epithelial cells against H2O2-induced oxidative damage in vitro.

Xudong SunRenxu ChangYan TangShengbin LuoChunhui JiangHongdou JiaQiushi XuZhihao DongYusheng LiangJuan J LoorChuang Xu

Published in: Journal of animal science and biotechnology (2021)

Our results indicate that activation of TFEB mediated autophagy alleviates H2O2-induced oxidative damage by reducing ROS accumulation and inhibiting caspase-dependent apoptosis.

Keyphrases

cell death
endoplasmic reticulum stress
oxidative stress
diabetic rats
transcription factor
signaling pathway
high glucose
cell cycle arrest
induced apoptosis
drug induced
dna damage
mouse model
dna binding