Rapamycin Improves Adipose-Derived Mesenchymal Stem Cells (ADMSCs) Renoprotective Effect against Cisplatin-Induced Acute Nephrotoxicity in Rats by Inhibiting the mTOR/AKT Signaling Pathway.

Amira AwadallaAbdelaziz M HusseinYousra M El-FarFardous F El-SendunyNashwa BarakatEman T HamamHanaa M AbdeenMohamed El Sherbiny Mohamed S SerriaAmira A SarhanAsmaa M SenaAhmed A Shokeir

Published in: Biomedicines (2022)

We concluded that the preactivation of autophagy with Rapa improves the survival and differentiation of the transplanted ADMSCs by inhibiting the mTOR/AKT signaling pathway, which in turn could significantly attenuate the Cis-induced acute renal injury.

Keyphrases

signaling pathway
mesenchymal stem cells
pi k akt
induced apoptosis
cell proliferation
epithelial mesenchymal transition
umbilical cord
bone marrow
sensitive detection
living cells
cell therapy
drug induced
oxidative stress
diabetic nephropathy