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C-H γ,γ,γ-Trifluoroalkylation of Quinolines via Visible-Light-Induced Sequential Radical Additions.

Yuhei KumagaiNanami MurakamiFuta KamiyamaRyo TanakaTatsuhiko YoshinoMasahiro KojimaShigeki Matsunaga
Published in: Organic letters (2019)
The photocatalyst-free C-H γ,γ,γ-trifluoroalkylation of quinolines under visible light irradiation is reported. By the combination of readily available alkenes and Umemoto's reagent II, a variety of γ,γ,γ-trifluoroalkyl groups were installed into quinolines via chemoselective sequential radical processes. This transformation provides rapid access to a variety of quinoline derivatives with scarcely explored fluoroalkyl groups, affording a novel library of N-heteroaromatic compounds and versatile building blocks for applications in medicinal chemistry.
Keyphrases
  • visible light
  • molecular docking
  • radiation induced
  • drug discovery
  • structure activity relationship