The current progress in the use of boron as a platform for novel antiviral drug design.

Shuo WangYujie RenZhao WangXiangyi JiangShujing XuXujie ZhangShujie ZhaoWaleed A ZalloumXinyong LiuPeng Zhan

Published in: Expert opinion on drug discovery (2022)

Compounds bearing boronic acid can interact with viral targets by forming covalent or robust hydrogen bonds. This feature is valuable for combating resistant viruses. Furthermore, boron clusters can form dihydrogen bonds and bear features such as three-dimensional aromaticity, hydrophobicity, and biological stability. All these features demonstrated boron as a probable essential element with immense potential for drug design.

Keyphrases

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machine learning
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risk assessment
transition metal
neural network
single cell
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