Poorly-Controlled Type 1 Diabetes Mellitus Impairs LH-LHCGR Signaling in the Ovaries and Decreases Female Fertility in Mice.

Jaewang Lee Hoi Chang Lee So Youn Kim Geum Joon Cho Teresa K Woodruff

Published in: Yonsei medical journal (2019)

These results suggest that T1D affects folliculogenesis, oogenesis, and embryo development in mice. However, the physiological mechanisms underlying the observed reproductive effects of diabetes need to be further investigated.

Keyphrases

high fat diet induced
glycemic control
type diabetes
cardiovascular disease
metabolic syndrome
young adults
insulin resistance
adipose tissue
cardiovascular risk factors
pregnancy outcomes