Methylphenidate Effects on Cortical Thickness in Children and Adults with Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.

Kristine Beate Walhovd Inge K Amlien Anouk Schrantee Darius Adam Rohani I Groote Atle Bjørnerud Anders Martin Martin Fjell Liesbeth Reneman

Published in: AJNR. American journal of neuroradiology (2020)

Our finding that the effects of methylphenidate on right medial cortical thickness differ between children and adults infers that the drug affects gray matter development in this brain region. This warrants replication in larger groups with longer follow-up to determine whether this effect can also be observed in other cortical brain regions and whether it may have long-term consequences.

Keyphrases

attention deficit hyperactivity disorder
young adults
white matter
resting state
optical coherence tomography
multiple sclerosis
emergency department
autism spectrum disorder
drug induced
subarachnoid hemorrhage
blood brain barrier