Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro.
Andrew T TemplinMahnaz MellatiDaniel T ZemanNathalie EsserMeghan F HoganJoseph J CastilloRehana AkterDaniel P RaleighSakeneh ZraikaRebecca L HullSteven E KahnPublished in: Diabetologia (2020)
Under amyloidogenic conditions, physiologically relevant levels of IL-1β promote islet amyloid formation by increasing beta cell release of IAPP. Neutralisation of this effect of IL-1β may decrease the deleterious effects of islet amyloid formation on beta cell function and survival.
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