Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model.

Man ChenLin-Lin YangZi-Wei HuChuan QinLuo-Qi ZhouYa-Ling DuanDale B BoscoLong-Jun WuKe-Bin ZhanSha-Bei XuDai-Shi Tian

Published in: Journal of neuroinflammation (2020)

These results suggested that microglial Hv1 deficiency ameliorates demyelination through inhibition of ROS-mediated autophagy and microglial phenotypic transformation.

Keyphrases

cell death
mouse model
inflammatory response
lipopolysaccharide induced
lps induced
neuropathic pain
dna damage
reactive oxygen species
high glucose
oxidative stress
replacement therapy
spinal cord
spinal cord injury
drug induced