Synergistic enhancement of the mouse Pramex1 and Pramel1 in repressing retinoic acid (RA) signaling during gametogenesis.
Mingyao YangFrancisco DiazAna Rita T KrauseYuguo LeiWan-Sheng LiuPublished in: Cell & bioscience (2024)
Data from sKO and dKO mice unveil a synergistic interaction via the RA signaling pathway between Pramex1 and Pramel1 genes during gametogenesis. This discovery sets the stage for investigating interactions among other members within the Prame family, advancing our understanding of multi-copy gene families involved in germ cell formation and function.
Keyphrases
- germ cell
- signaling pathway
- rheumatoid arthritis
- genome wide
- genome wide identification
- cancer therapy
- disease activity
- small molecule
- electronic health record
- ankylosing spondylitis
- pi k akt
- copy number
- genome wide analysis
- epithelial mesenchymal transition
- high fat diet induced
- high throughput
- big data
- interstitial lung disease
- drug delivery
- transcription factor
- bioinformatics analysis
- machine learning
- gene expression