Linaclotide increases cecal pH, accelerates colonic transit, and increases colonic motility in irritable bowel syndrome with constipation.
Adam Donald FarmerJames K RuffleAnthony R HobsonPublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2018)
Linaclotide's effects are confined to the colon where it increases cecal pH, potentially representing a reduction in cecal fermentation and accelerates colonic motility.