Microsecretory adenocarcinoma of the skin harboring recurrent SS18 fusions: A cutaneous analog to a newly described salivary gland tumor.

Justin A BishopErik A WilliamsAnne C McLeanJeffrey GaganLisa M RooperRichard C K JordanPhilip E LeBoit

Published in: Journal of cutaneous pathology (2022)

This report expands the sites that can be involved by MSA. Similar to salivary cases, MEF2C::SS18 represents a recurrent fusion in MSA of the skin. Unusual features in cutaneous cases not seen in salivary MSA include one case with high-grade transformation and two cases with a myoepithelial cell component. Identification of this fusion expands the spectrum of salivary-analog cutaneous tumors and aids in precise tumor classification.

Keyphrases

high grade
soft tissue
machine learning
wound healing
squamous cell carcinoma
single cell
low grade
deep learning
cell therapy
stem cells
locally advanced