Association of Circulating Vitamin D With Colorectal Cancer Depends on Vitamin D-Binding Protein Isoforms: A Pooled, Nested, Case-Control Study.
David Corley GibbsMingyang SongMarjorie L McCulloughCaroline Y UmRoberd M BostickKana WuW Dana FlandersEdward GiovannucciMazda JenabMagritt BrustadAnne TjønnelandAurora Perez-CornagoAntonia TrichopoulouKonstantinos K TsilidisJohan HultdinAurelio Barricarte GurreaBas Bueno-de-MesquitaYahya Mahamat-SalehTilman KühnMarc J GunterElisabete WeiderpassVeronika FedirkoPublished in: JNCI cancer spectrum (2019)
Our results suggest that the 25(OH)D-CRC association may differ by DBP isoform, and those with a DBP2-encoding genotype linked to vitamin D insufficiency may particularly benefit from adequate 25(OH)D for CRC prevention.
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