Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum.
Mark A DubbelmanRoos J JuttenSarah E Tomaszewski FariasRebecca E AmariglioRachel F BuckleyPieter Jelle VisserDorene M RentzKeith A JohnsonMichael J ProperziAaron SchultzNancy DonovanJennifer R GatchellCharlotte E TeunissenBart N M Van BerckelWiesje M Van der FlierReisa A SperlingKathryn V PappPhilip ScheltensGad A MarshallSietske A M Sikkesnull nullPublished in: Alzheimer's research & therapy (2020)
Our results suggest that the rate of functional decline accelerates along the AD continuum, as shown by steeper rates of decline in each successive NIA-AA clinical stage. These results imply that incremental changes in function are a meaningful measure for early disease monitoring. Combined with the low-cost assessment, this advocates the use of these functional questionnaires for capturing the effects of early AD-related cognitive decline on daily life.