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Lesions sub-diagnostic of endometrioid intra-epithelial neoplasia/atypical hyperplasia: value of morphology and immunohistochemistry in predicting neoplastic outcome.

Nicolas WyvekensGeorge L MutterMarisa R NucciDavid L KolinCarlos Parra-Herran
Published in: Histopathology (2024)
The presence of SL warrants clinical surveillance and repeat sampling because it is followed by endometrioid neoplasia in a significant subset of patients. Normal three-marker staining identifies women with a very low risk of neoplastic outcome. Conversely, abnormal staining is frequent in SL with benign outcome leading to poor specificity and positive predictive value.
Keyphrases
  • end stage renal disease
  • high grade
  • endometrial cancer
  • ejection fraction
  • chronic kidney disease
  • public health
  • flow cytometry
  • dna methylation
  • patient reported