Epistatic Features and Machine Learning Improve Alzheimer's Risk Prediction Over Polygenic Risk Scores.
Stephen HermesJanet CadySteven ArmentroutJames O'ConnorSarah CarlsonCruchaga CarlosThomas S WingoEllen McRae Greytaknull nullPublished in: medRxiv : the preprint server for health sciences (2023)
Paragenic models show potential for improving lifetime disease risk prediction for complex heritable diseases such as LOAD over PRS models.