A splice-switch oligonucleotide loaded self-cleavable DNA nanogel.
Yuwei HuFeng ChenHongfang LuSusi TanYujie KeWei Wei LohEugene Jia Hao SohAgarwal TaniyaTommaso TabaglioDave Keng Boon WeeJackie Y YingPublished in: Chemical communications (Cambridge, England) (2024)
A self-cleavable DNA nanogel loaded with splice-switch oligonucleotide (SSO) has been developed. Under acidic conditions (pH 5.0), cleavage of the acid-labile chemical linker and generation of the i-motif structure led to the disintegration of the DNA nanogel and efficient release of SSO in its unaltered native state.