Promiscuous Structural Variants Drive Myeloma Initiation and Progression.

Published in: Blood cancer discovery (2020)

A comprehensive genomic analysis of structural variants in multiple myeloma in this issue highlights the key role of these events, involving primarily the immunoglobulin heavy chain locus in disease initiation and the MYC locus in disease progression. However, the current study reveals the large number of genomic hotspots, oncogenes, tumor suppressor genes, and recombination mechanisms that contribute to multiple myeloma heterogeneity. See related article by Rustad et al., p. 258.

Keyphrases

multiple myeloma
copy number
genome wide
dna damage
dna methylation
genome wide association study
single cell
transcription factor
gene expression
bioinformatics analysis
drug induced