Two novel type 2 diabetes loci revealed through integration of TCF7L2 DNA occupancy and SNP association data.
Matthew E JohnsonJianhua ZhaoJonathan SchugSandra DeliardQianghua XiaVanessa C GuyJesus SainzKlaus H KaestnerAndrew D WellsStruan F A GrantPublished in: BMJ open diabetes research & care (2014)
ChIP-seq data generated with this GWAS-implicated transcription factor provided a biologically plausible method to limit multiple testing in the assessment of genome-wide genotyping data to uncover two novel T2D-associated loci.
Keyphrases
- genome wide
- dna methylation
- type diabetes
- electronic health record
- transcription factor
- copy number
- big data
- single cell
- high throughput
- cardiovascular disease
- gene expression
- data analysis
- machine learning
- genome wide association study
- insulin resistance
- circulating tumor
- cell free
- weight loss
- skeletal muscle
- nucleic acid
- metabolic syndrome