Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation.
Chak-Shing KwanTao WangMin LiAlbert S C ChanZongwei CaiKen Cham-Fai LeungPublished in: Chemical communications (Cambridge, England) (2019)
Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.