AM1172 (a hydrolysis-resistant endocannabinoid analog that inhibits anandamide cellular uptake) reduces the viability of the various melanoma cells, but it exerts significant cytotoxic effects on healthy cells: an in vitro study based on isobolographic analysis.

Paweł Marzęda Paula Wróblewska-Łuczka Magdalena Florek-Łuszczki Agnieszka Góralczyk Jarogniew J Luszczki

Published in: Pharmacological reports : PR (2023)

AM1172 cannot be used separately as a chemotherapeutic drug, but it can be combined with PACX, DOCX, MTX, and CDDP, offering additive interactions in terms of the anti-proliferative effects in various malignant melanoma cell lines.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
signaling pathway
emergency department
adverse drug