Microglial Gi-dependent dynamics regulate brain network hyperexcitability.
Mario MerliniVictoria A RafalskiKeran MaKeun-Young KimEric A BushongPamela E Rios CoronadoZhaoqi YanAndrew S MendiolaElif G SozmenJae Kyu RyuMatthias Georg HaberlMatthew MadanyDaniel Naranjo SampsonMark A PetersenSophia BardehleReshmi TognattaTerry DeanRosa Meza AcevedoBelinda CabrigaReuben ThomasShaun R CoughlinMark H EllismanJorge J PalopKaterina AkassoglouPublished in: Nature neuroscience (2020)
Microglial surveillance is a key feature of brain physiology and disease. Here, we found that Gi-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating MgPTX mice to genetically inhibit Gi in microglia, we show that sustained reduction of microglia brain surveillance and directed process motility induced spontaneous seizures and increased hypersynchrony after physiologically evoked neuronal activity in awake adult mice. Thus, Gi-dependent microglia dynamics may prevent hyperexcitability in neurological diseases.
Keyphrases
- inflammatory response
- neuropathic pain
- cerebral ischemia
- resting state
- lipopolysaccharide induced
- lps induced
- white matter
- public health
- functional connectivity
- spinal cord
- spinal cord injury
- high fat diet induced
- machine learning
- subarachnoid hemorrhage
- blood brain barrier
- high glucose
- escherichia coli
- pseudomonas aeruginosa
- cystic fibrosis
- adipose tissue
- deep learning
- stress induced