Lung and blood early biomarkers for host-directed tuberculosis therapies: Secondary outcome measures from a randomized controlled trial.
Robert S WallisSibuse GinindzaTrevor BeattieNishanee ArjunMorongwe LikotiModulakgotla SebeVinodh A EdwardMohammed RassoolKhatija AhmedKatherine FieldingBintou A AhidjoMboyo D T VanguGavin ChurchyardPublished in: PloS one (2022)
None of these early biomarkers correctly predicted HDT effects on inflammation or infection across all four experimental arms. Instead, they each appear to show highly specific responses related to HDT mechanisms of action.