Factors influencing the acute pentylenetetrazole-induced seizure paradigm and a literature review.

Christopher J Yuskaitis Leigh-Ana RossittoKarenna J GroffSameer C DhamneBo ZhangLahin K LalaniAchint K SinghAlexander Rotenberg Mustafa Sahin

Published in: Annals of clinical and translational neurology (2021)

Our analysis and literature review demonstrate a critical gap in standardization of acute PTZ-induced seizure paradigm in mice. We recommend that future studies specify and control for age, background strain, sex, and housing conditions of experimental animals.

Keyphrases

drug induced
liver failure
high glucose
case report
diabetic rats
respiratory failure
type diabetes
oxidative stress
current status
intensive care unit
temporal lobe epilepsy
insulin resistance