Differential Regional Vulnerability of the Brain to Mild Neuroinflammation Induced by Systemic LPS Treatment in Mice.
Hyeji JungHyojeong LeeDongwook KimEunji CheongYoung-Min HyunJe-Wook YuJi Won UmPublished in: Journal of inflammation research (2022)
Our results suggest that mild neuroinflammation induces regionally different microglia activation, producing pro-inflammatory cytokines. Our observations provide insight into induction of possible region-specific neuroinflammation-associated brain pathologies through microglial activation.
Keyphrases
- inflammatory response
- lipopolysaccharide induced
- lps induced
- cerebral ischemia
- traumatic brain injury
- resting state
- white matter
- cognitive impairment
- subarachnoid hemorrhage
- anti inflammatory
- functional connectivity
- neuropathic pain
- brain injury
- climate change
- multiple sclerosis
- type diabetes
- adipose tissue
- high fat diet induced
- spinal cord
- wild type
- replacement therapy