Differential association between S100A4 levels and insulin resistance in prepubertal children and adult subjects with clinically severe obesity.

Siri D TaxeråsMaría GalánLaura CampderrosIrene Piquer-GarciaSilvia PelliteroEva MartínezRocío PuigIcíar LucenaJordi TarascóPau MorenoJosé BalibreaJoan BelMarta MurilloMaría MartínezMarta Ramon-KrauelManel Puig-DomingoFrancesc VillarroyaCarles Lerin David Sánchez-Infantes

Published in: Obesity science & practice (2019)

Our human data demonstrate that higher S100A4 levels are a marker of IR in adults with obesity but not in prepubertal children. Furthermore, the in vitro results suggest that S100A4 might exert an anti-inflammatory effect. Further studies will be necessary to determine whether S100A4 can be a therapeutic target for obesity.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
young adults
anti inflammatory
body mass index
electronic health record
machine learning
deep learning
induced pluripotent stem cells
data analysis
growth hormone