Mobilization characteristics, blood graft composition, and outcome in diffuse large B-cell lymphoma after autologous stem cell transplantation: Results from the prospective multicenter GOA study.

Partanen AnuAntti TurunenJaakko ValtolaMarja PyöräläKaija VasalaOuti KuittinenHanne KuitunenKarri PenttiläLeena KeskinenTaru KuittinenPentti MäntymaaJukka PelkonenVille VarmavuoEsa Jantunen

Published in: Transfusion (2020)

The mobilization capacity of CD34+ cells impacted on early hematologic recovery in patients with DLBCL after auto-SCT. Higher graft CD34+ cell count and both CD34+ CD133+ CD38- and CD3+ cells were also associated with better OS. The effect of optimal graft cellular composition on outcome in DLBCL should be evaluated in a randomized study.

Keyphrases

diffuse large b cell lymphoma
stem cell transplantation
induced apoptosis
epstein barr virus
cell cycle arrest
high dose
nk cells
single cell
stem cells
clinical trial
oxidative stress
cell death
low dose
cell proliferation
double blind