Pulsed-Reduced Dose Rate (PRDR) Radiotherapy for Recurrent Primary Central Nervous System Malignancies: Dosimetric and Clinical Results.

Tugce KutukRanjini TolakanahalliNicole C McAllisterMatthew D HallMartin C TomMuni RubensHaley AppelAlonso N GutierrezYazmin OdiaAlexander MohlerManmeet S AhluwaliaMinesh P MehtaRupesh Kotecha

Published in: Cancers (2022)

PRDR re-irradiation is a relatively safe and feasible treatment for recurrent primary CNS tumors. Despite high cumulative dose to OARs, the risk of high-grade, treatment-related toxicity within the first year of follow-up remains acceptable.

Keyphrases

high grade
radiation therapy
early stage
oxidative stress
radiation induced
low grade
blood brain barrier
combination therapy
rectal cancer
oxide nanoparticles