Genetic variants on chromosomes 7p31 and 12p12 are associated with abnormal atrial electrical activation in patients with early-onset lone atrial fibrillation.

Mariam B SeifertMorten S OlesenIngrid E ChristophersenJonas B NielsenJonas CarlsonFredrik HolmqvistArnljot TveitStig HaunsøJesper H SvendsenPyotr G Platonov

Published in: Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2019)

In this study, the two variants rs3807989 and rs11047543, previously associated with PR interval and lone AF, were associated with altered P-wave morphology distribution in patients with early-onset lone AF. These findings suggest that common genetic variants may modify atrial conduction properties.

Keyphrases

early onset
atrial fibrillation
catheter ablation
late onset
left atrial
oral anticoagulants
left atrial appendage
direct oral anticoagulants
heart failure
percutaneous coronary intervention
copy number
left ventricular
acute coronary syndrome