Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment.
Zachary Stephen ClaytonMatthew J RossmanSophia A MahoneyRavinandan VenkatasubramanianGrace S MaurerDavid A HuttonNicholas S VanDongenNathan T GreenbergAbigail G LongtineKatelyn R LudwigVienna E BruntThomas J LaRoccaPierre-Yves DesprezSimon MelovDouglas R SealsPublished in: Hypertension (Dallas, Tex. : 1979) (2023)
Cellular senescence and the SASP contribute to vascular aging, and senolytics hold promise for improving age-related vascular function.