IL-2mAb reduces demyelination after focal cerebral ischemia by suppressing CD8+ T cells.

Yu-Xi ZhouXin WangDan TangYan LiYing-Fu JiaoYu GanXiao-Ming HuLi-Qun YangWei-Feng YuRuth Anne StetlerPei-Ying LiDa-Xiang Wen

Published in: CNS neuroscience & therapeutics (2018)

IL-2mAb preserved white matter integrity and improved long-term sensorimotor functions following cerebral ischemic injury. The activation and brain infiltration of CD8+ T cells are detrimental for demyelination after stroke and may be the major target of IL-2mAb posttreatment in the protection of white matter integrity after stroke.

Keyphrases

cerebral ischemia
white matter
subarachnoid hemorrhage
blood brain barrier
brain injury
multiple sclerosis
monoclonal antibody
functional connectivity
resting state