Mouse model of metformin-induced diarrhea.

Hiroshi TakemoriAkie HamamotoKenta IsogawaMasafumi ItoMasanori TakagiHirofumi MorinoTakanori MiuraKyoichi OshidaTakashi Shibata

Published in: BMJ open diabetes research & care (2021)

We have created the first animal model of metformin-induced diarrhea using db/db mice, which will provide better quality of life for patients suffering from diarrhea caused by metformin.

Keyphrases

mouse model
high glucose
irritable bowel syndrome
end stage renal disease
diabetic rats
clostridium difficile
ejection fraction
chronic kidney disease
newly diagnosed
drug induced
prognostic factors
endothelial cells
patient reported outcomes
adipose tissue
skeletal muscle