Preparation of 2D Polyaniline/MoO 3-x Superlattice Nanosheets Via Intercalation-Induced Morphological Transformation for Efficient Chemodynamic Therapy.

Organic intercalation of layered nanomaterials is an attractive strategy to fabricate organic/inorganic superlattices for a wide range of promising applications. However, the synthesis of two-dimensional (2D) organic/inorganic superlattice nanosheets remains a big challenge. Herein, we report the preparation of 2D polyaniline/MoO 3- x (PANI/MoO 3- x ) superlattice nanosheets via intercalation-induced morphological transformation from MoO 3 nanobelts as efficient Fenton-like reagents for chemodynamic therapy (CDT). Micrometer-long MoO 3 nanobelts are co-intercalated with Na + /H 2 O followed by the guest exchange with aniline monomer for in-situ polymerization to obtain PANI/MoO 3- x nanosheets. Intriguingly, the PANI intercalation can induce the morphological transformation from long MoO 3 nanobelts to 2D PANI/MoO 3-x nanosheets along with the partially reduction of Mo 6+ to Mo 5+ , and generation of rich oxygen vacancies. More importantly, thanks to the PANI intercalation-induced activation, the PANI/MoO 3- x nanosheets exhibit excellent Fenton-like catalytic activity for generation of hydroxyl radical (·OH) by decomposing H 2 O 2 compared with the MoO 3 nanobelts. It is speculated that the good conductivity of PANI could facilitate electron transport during the Fenton-like reaction, thereby enhancing the efficiency of CDT. Thus, the polyvinylpyrrolidone-modified PANI/MoO 3- x nanosheets can function as Fenton-like reagents for highly efficient CDT to kill cancer cells and eradicate tumors. This article is protected by copyright. All rights reserved.