Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip.

Micah O MazurekJunichi NakamuraShigeo HagiwaraMiyako Suzuki-NaritaKazuhide InageSeiji Ohtori

Published in: Journal of orthopaedic surgery and research (2024)

The intra-articular administration of monoiodoacetate induced hip joint OA and decreased pain threshold. The DNA methylation machinery in the synovial tissues of hip OA was altered.

Keyphrases

dna methylation
total hip arthroplasty
gene expression
knee osteoarthritis
genome wide
chronic pain
rheumatoid arthritis
high glucose
pain management
drug induced
copy number
oxidative stress
spinal cord