Aim: Neurofilament light chain (NfL) is a nonspecific sensitive biomarker of axonal damage. Methods: This case series identified cancer patients with neurological complications who had serum NfL measurements and paired these results to outcomes. Results: NfL serum levels were available in 15 patients with hematological malignancies or solid tumors. The neurological complications studied were immune effector cell-associated neurotoxicity syndrome, immune checkpoint inhibitor-related encephalopathy, anoxic brain injury, Guillain-Barre syndrome, hemophagocytic lymphohistiocytosis, transverse myelitis, paraneoplastic syndrome, central nervous system demyelinating disorder and chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids. All patients but one with serum NfL >900 pg/ml died during hospitalization. Conclusion: Serum NfL levels consistently corresponded to death, disease severity or recovery in this series.
Keyphrases
- brain injury
- papillary thyroid
- cerebrospinal fluid
- subarachnoid hemorrhage
- cerebral ischemia
- end stage renal disease
- oxidative stress
- risk factors
- case report
- ejection fraction
- chronic kidney disease
- prognostic factors
- type diabetes
- squamous cell carcinoma
- cell therapy
- regulatory t cells
- single cell
- stem cells
- adipose tissue
- skeletal muscle
- bone marrow
- insulin resistance
- optic nerve