Effect of short-term prescription opioids on DNA methylation of the OPRM1 promoter.

Jose Vladimir Sandoval-SierraFrancisco I Salgado GarcíaJeffrey H BrooksKaren J DerefinkoKhyobeni Mozhui

Published in: Clinical epigenetics (2020)

The present study provides evidence that the hypermethylation of the OPRM1 promoter is in response to opioid use and that epigenetic differences in OPRM1 and other sites are associated with a short-term use of therapeutic opioids.

Keyphrases

dna methylation
gene expression
genome wide
chronic pain
pain management
copy number