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Noisy Delay Denoises Biochemical Oscillators.

Yun Min SongSean CampbellLieJune ShiauJae Kyoung KimWilliam Ott
Published in: Physical review letters (2024)
Genetic oscillations are generated by delayed transcriptional negative feedback loops, wherein repressor proteins inhibit their own synthesis after a temporal production delay. This delay is distributed because it arises from a sequence of noisy processes, including transcription, translocation, translation, and folding. Because the delay determines repression timing and, therefore, oscillation period, it has been commonly believed that delay noise weakens oscillatory dynamics. Here, we demonstrate that noisy delay can surprisingly denoise genetic oscillators. Specifically, moderate delay noise improves the signal-to-noise ratio and sharpens oscillation peaks, all without impacting period and amplitude. We show that this denoising phenomenon occurs in a variety of well-studied genetic oscillators, and we use queueing theory to uncover the universal mechanisms that produce it.
Keyphrases
  • high frequency
  • air pollution
  • genome wide
  • transcription factor
  • dna methylation
  • machine learning