The role of proteasome in muscle wasting of experimental arthritis.
Vivian Oliveira Nunes TeixeiraBárbara Jonson BartikoskiRafaela Cavalheiro do Espírito SantoPaulo Vinícius Gil AlabarseKhetam GhannanJordana Miranda Souza SilvaLidiane Isabel FilippinFernanda VisioliLorena Martinez-GamboaEugen FeistRicardo Machado XavierPublished in: Advances in rheumatology (London, England) (2023)
The results of CIA-Vehicle show that arthritis increases muscle proteasome activation by enhanced caspase-like activity of 26S proteasome and increased PSMβ8 and PSMβ9 mRNA levels. Etanercept treatment was able to maintain the muscle weight and to modulate proteasome so that its activity and gene expression were compared to CO after TNF inhibition. The protein expression of inflammation-induced proteasome subunit was increased in muscle of CIA-MTX group but not following etanercept treatment. Thus, anti-TNF treatment may be an interesting approach to attenuate the arthritis-related muscle wasting.