Lower baseline autoantibody levels are associated with immune-related adverse events from immune checkpoint inhibition.
Nilasha GhoshMichael A PostowChengsong ZhuDeanna Jannat-KhahQuan-Zhen LiGreg VitoneKarmela K ChanAnne R BassPublished in: Journal for immunotherapy of cancer (2022)
Patients with low autoantibody concentrations at baseline as well as a greater FC in autoantibody concentration over 6 weeks developed more distinct organ-specific irAE. This may suggest differences in the balance of cellular immunity and humoral pathways that are relevant in the pathogenesis of irAE, though further investigation is needed.