Cognitive Improving Effects by Highbush Blueberry (Vaccinium crymbosum L.) Vinegar on Scopolamine-Induced Amnesia Mice Model.
Seong Min HongKyong Hee SoeTaek Hwan LeeIn Sook KimYoung Min LeeBeong Ou LimPublished in: Journal of agricultural and food chemistry (2017)
The present study aimed to evaluate the preventive effects of highbush blueberry (Vaccinium corymbosum L.) vinegar (BV) on cognitive functions in a scopolamine (Sco)-induced amnesia model in mice. In this study, Sco (1 mg/kg, intraperitoneal injection) was used to induce amnesia. ICR mice were orally administered donepezil (5 mg/kg), blueberry extract (120 mg/kg), and BV (120 mg/kg) for 7 days. After inducing cognitive impairment by Sco, a behavioral assessment using behavior tests (i.e., Y-maze and passive avoidance tests) was performed. The BV group showed significantly restored cognitive function in the behavioral tests. BV facilitated cholinergic activity by inhibiting acetylcholinesterase activity, and enhanced antioxidant enzyme activity. Furthermore, BV was found to be rehabilitated in the cornu ammonis 1 neurons of hippocampus. In our study, we demonstrated that the memory protection conferred by BV was linked to activation of brain-derived neurotrophic factor (BDNF)/cAMP response element binding protein (CREB)/serine-threonine kinase (AKT) signaling.
Keyphrases
- lps induced
- lipopolysaccharide induced
- cognitive impairment
- binding protein
- oxidative stress
- signaling pathway
- high fat diet induced
- inflammatory response
- cell proliferation
- protein kinase
- metabolic syndrome
- spinal cord injury
- endothelial cells
- skeletal muscle
- insulin resistance
- brain injury
- subarachnoid hemorrhage
- blood brain barrier
- drug induced