Asymmetric synthesis of enantioenriched α-allyl esters through Pd(BINAPHANE)-catalysed allylation of disubstituted ketenes.
Ahmad A IbrahimStephen C J O'ReillyMargot BottarelNessan J KerriganPublished in: Chemical communications (Cambridge, England) (2024)
Pd 2 dba 3 ·CHCl 3 (2.5 mol%)-BINAPHANE (5 mol%) was used to promote the first catalytic enantioselective allylation of disubstituted ketenes to give α-allyl esters. The ester products were formed in good to excellent yields (61-93% yield for 13 examples, 16 examples in all), with moderate to good enantioselectivity (68-80% ee for 7 examples).