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GRK5 Inhibition Attenuates Cartilage Degradation via Decreased NF-κB Signaling.

Takuya SueishiYukio AkasakiNorio GotoIchiro KurakazuMasakazu ToyaMasanari KuwaharaTaisuke UchidaMitsumasa HayashidaHidetoshi TsushimaHirofumi BekkiMartin K LotzYasuharu Nakashima
Published in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our results suggest that GRK5 regulates cartilage degradation through a catabolic response mediated by NF-κB signaling, and is a potential target for OA treatment. Furthermore, amlexanox may be a major compound in relevant drugs.
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