Parkinson's-linked LRRK2-G2019S derails AMPAR trafficking, mobility and composition in striatum with cell-type and subunit specificity.

Swati GuptaChristopher A GuevaraAlexander TielemansGeorge W Huntley Deanna L Benson

Published in: bioRxiv : the preprint server for biology (2023)

R SPNs and negatively impacts synapse strengthening as GluA1-AMPARs fail to increase at the surface in response to potentiation and show limited surface mobility. Thus, LRRK2-G2019S narrows the effective range of plasticity mechanisms, supporting the idea that cognitive symptoms reflect an imbalance in AMPAR trafficking mechanisms within cell-type specific projections.

Keyphrases

depressive symptoms
structural basis