Overall survival, disease-free survival and quality of life in patients affected by HPV mediated p16+ oropharyngeal squamous cell carcinoma treated with upfront trans-oral robotic surgery vs radiotherapy or chemoradiotherapy.

Giacomo FiacchiniMiriana PicarielloIacopo DallanDomenico TricòAugusto Pietro CasaniFederica AmatoFabiola PaiarStefano UrsinoStefano BerrettiniLuca Bruschini

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2024)

For p16 + OPSCC PSG I patients, upfront surgery can be considered a valid alternative to radiotherapy or chemoradiotherapy while maintaining a comparable DFS and OS and giving patients better results in terms of specific aspects of their QoL.

Keyphrases

squamous cell carcinoma
end stage renal disease
newly diagnosed
ejection fraction
locally advanced
prognostic factors
free survival
radiation therapy
acute coronary syndrome
radiation induced
patient reported
lymph node metastasis