Comparison of different cell type correction methods for genome-scale epigenetics studies.

Akhilesh KaushalHongmei ZhangWilfried J J KarmausMeredith RayMylin A TorresAlicia K SmithShu-Li Wang

Published in: BMC bioinformatics (2017)

Results from real data and simulations indicated that SVA is recommended when the focus is on the identification of informative CpGs. When appropriate reference data are available, the method implemented in the minfi package is recommended. However, if no such reference data are available or if the focus is not on estimating cell proportions, the SVA method is suggested.

Keyphrases

electronic health record
big data
single cell
machine learning
data analysis
gene expression
bone marrow
genome wide
deep learning
clinical evaluation
monte carlo