Effect modification of polypharmacy on incident frailty by chronic kidney disease in older adults.

Nina Mielke Muhammad Helmi Barghouth Anne-Katrin Fietz Cédric Villain Tim Bothe Natalie Ebert Elke Schäffner

Published in: BMC geriatrics (2024)

This study demonstrates an association of polypharmacy and incident frailty and suggests strong evidence for an effect modification of CKD on polypharmacy and incident frailty. Revision of prescriptions could be a target strategy to prevent frailty occurrence, especially in older adults with CKD.

Keyphrases

chronic kidney disease
community dwelling
end stage renal disease
cardiovascular disease
physical activity
adverse drug
risk assessment
total knee arthroplasty
electronic health record