Autoantibodies associated with systemic sclerosis in three autoimmune diseases imprinted by type I interferon gene dysregulation: a comparison across SLE, primary Sjögren's syndrome and systemic sclerosis.
Rama AndraosAwais AhmadPer ErikssonÖrjan DahlströmLina WirestamCharlotte DahleRoger HesselstrandAnders A BengtssonAndreas JönsenKristofer AndréassonChristopher SjöwallPublished in: Lupus science & medicine (2023)
The 13 specificities included in the EuroLine immunoassay are commonly detected in SSc, but they are also frequent among individuals with other diseases imprinted by type I IFNs. These findings are valuable when interpreting serological data on patients with suspected SSc, especially as patients may present with disease manifestations overlapping different rheumatological diseases. In SLE, we observed associations between manifestations and SSc-associated autoantibodies which have not previously been reported.
Keyphrases
- systemic sclerosis
- systemic lupus erythematosus
- interstitial lung disease
- disease activity
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- peritoneal dialysis
- dendritic cells
- rheumatoid arthritis
- prognostic factors
- big data
- sensitive detection
- transcription factor
- idiopathic pulmonary fibrosis
- dna methylation