Neuronal fate specification by the Dbx1 transcription factor is linked to the evolutionary acquisition of a novel functional domain.

Sonia KarazMaximilien CourgeonHélène LepetitEugenia BrunoRaimondo PannoneAndrea TaralloFrance ThouzéPierre KernerMichel VervoortFrédéric CauseretAlessandra PieraniGiuseppe D'Onofrio

Published in: EvoDevo (2016)

Our results strongly suggest that the presence of a Cter domain among tetrapods is essential for Dbx1 to regulate neuronal diversity and, in turn, nervous system complexity.

Keyphrases

transcription factor
cerebral ischemia
genome wide
sensitive detection
living cells
cell fate
brain injury
single molecule