Sarcoma Cells Secrete Hypoxia-Modified Collagen VI to Weaken the Lung Endothelial Barrier and Promote Metastasis.

Ying Liu Ileana Murazzi Ashley M Fuller Hehai Pan Valerie M Irizarry-Negron Ann DeVine Rohan Katti Nicolas Skuli Gabrielle E Ciotti Koreana Pak Michael A Pack M Celeste Simon Kristy L Weber Kumarasen Cooper T S Karin Eisinger-Mathason

Published in: Cancer research (2024)

Collagen type VI modified by hypoxia-induced PLOD2 is secreted by sarcoma cells and binds to integrin β1 on endothelial cells to induce barrier dysfunction, which promotes sarcoma vascular dissemination and metastasis.

Keyphrases

endothelial cells
induced apoptosis
cell cycle arrest
cell death
signaling pathway
wound healing
high glucose
vascular endothelial growth factor